Estronex: A Simple Test to Evaluate a Woman’s Risk for Cancer

by Dr. Kilcup | Apr 9, 2015 | Articles, Cancer, Toxins And Detox, Womans Health

The American Cancer Society estimates 231,804 new cases of breast cancer in 2015.  In 2010 the same organization estimated 207,909 new cases of breast cancer.  As with all cancers, prevention is the best treatment.  Estronex is a simple urine test that determines if a woman is at risk for estrogen-sensitive cancers and provides a plan to reduce that risk.  How cool is that?  If a person wants to be proactive in preventing cancers like breast cancer, colorectal cancer, uterine cancers, ovarian cancer and cervical cancer this is a “must have” test.

This is a big deal people!

Breast cancer is the FIRST most common cause of cancer death in women!  Did you notice those numbers in the first two sentences?  The number of breast cancer deaths is INCREASING!  Look, if you’re okay with those numbers, just keep doing what you’re doing!  However, if you would like to DO SOMETHING to help prevent cancer, then keep reading.

Risk factors for estrogen-sensitive cancers include:

• Prolonged use of oral contraceptives(5+ years)
• Synthetic hormone replacement therapy
• Family or personal history of breast cancer
• Obesity or sedentary lifestyle
• Consumption of 2 or more alcoholic drinks per day
• Getting older
• Never having children, or having your first after age 30
• Having high breast density shown on a mammogram
• Being exposed to large amounts of radiation

Anyone with some of these risk factors should consider getting the Estronex profile done.

To help you understand how Estronex works check out this diagram:


At the top of the diagram is DHEA.  I call DHEA a “Mother Hormone” because almost all hormones are made from DHEA.  The body takes DHEA and turns it into Estrone.  Estrone is one of the main hormones that we check with blood work.  Depending primarily on genetics, lifestyle, supplements and diet, Estrone is converted into either a good estrogen or a bad estrogen.

The good estrogen is called 2-hydroxyestrone (2-OHE1).  This hero hormone does two things to help prevent cancer.  Firstly, the good estrogen discourages the multiplication of cancer cells.  Secondly, the good estrogen protects tissue that is under the influence of estrogen, like breast, cervical, uterine, and prostate tissue, from the bad estrogens.  Yea good estrogen!

The bad estrogen is called 16-α-hydroxyestrone (16α-OHE1).  The way the evil hormone helps cancer is that it accelerates the rate at which cancer cells multiply.  Boo bad estrogen!

The Estronex test measures the amount of the good and bad estrogens.  The best result is to have a ratio between the good and bad estrogen of 2:1 or higher, because people with a really low ratio have a much greater risk of estrogen-sensitive cancers.

The things that can lead to a low or bad ratio of good to bad estrogen are:

  • Birth Control Pills
  • High Levels of Toxins
    • Plastic
    • Smoking
    • Heavy Metals
    • Pesticides
  • Hypothyroidism
  • Obesity or Sedentary Lifestyle
  • High Fat, Low Fiber Diet
  • High Omega-6 Fatty Acids
  • Alcohol Consumption
  • Synthetic hormone replacement therapy

These things help increase a low (bad) ratio:

  • Decrease coffee consumption and smoking
  • Reduce alcohol comsumption
  • Lower an elevated BMI
  • Supplement with indole-3-carbinol (I3C) or di-indolemethane (DIM)
  • Increase cruciferous vegetables including: broccoli, cabbage, and brussels sprouts
  • Supplement with dried organic brussels sprouts and kale
  • Increase ground flax seed
  • Increase intake of fish oils (omega-3 fatty acids)
  • Increase fruit and vegetable intake
  • Soy isoflavones (genestein, daidzein)
  • Consider alternatives to oral contraceptive use

If you’re an eager beaver and after reading this you decide to go all in with all the things that help increase the good estrogen, I need to caution you (but I like your style!)  If you get the good estrogen too high it can cause osteoporosis.  The body is all about balance.  The best way to go about this is to get the Estronex test and then take action based on individual results.

Whether you’ve already had one of these cancers, or you already have these risk factors, or you just want to take good care of yourself, this test is for you.  I can help you even if you can’t physically come into my office.  This is powerful information that will give you direction on what you need to be doing or not doing to lower your risk of estrogen-sensitive cancers.

Now don’t just sit there, ask me a question or make a comment!  Seriously, do your part in helping reduce the number of these cancer deaths.  Your part might be for you to contact me and get tested, or it might be for you to pass this information on to a loved one, or just to post this on your social media.  Whatever you do, don’t feel like you should do something and not do it.  Cancer is serious stuff.

Darrell Kilcup, DC, CFMP

Hi there! I’m Dr. Kilcup. You know that health problem you’ve been dealing with – the one that doctors can’t seem to solve, that’s stealing way too much of your time, energy and joy? I can help you get to the bottom that. I am passionate about using the best of science and nutrition to find and fix root causes of health issues. Start your journey towards healing and relief today.

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