The Functional Medicine Approach to Preventing a Second Stroke

by Dr. Kilcup | Dec 16, 2025 | Articles, Stroke

A healthy man walking in a park with a digital overlay of brain neural pathways and vascular health icons, representing a functional medicine approach to preventing a second stroke.

Here’s the Truth: Why Your Stroke Risk Isn’t Gone

Let me be blunt. If you’ve had a stroke, you are now walking around with a giant target on your back. You’ve been through the absolute terror, the loss of function, and the brutal recovery. The last thing you want to hear is that the job isn’t done.

But I have to be straight with you: You are at significantly higher risk of having a second stroke.

And the scary part? For most people, the standard post-stroke care—the blood thinners, the statins, the basic diet advice—it’s like putting a tiny, ineffective Band-Aid on a major, systemic problem. They treat the event (the clot, the bleed) but they completely miss the root cause that made your blood vessels vulnerable in the first place.

Think of it this way: The standard medical system is amazing at getting you out of the burning house. But then they send you home without ever asking why the fire started. Was it faulty wiring? A gas leak? Until you figure out the cause of the fire, the house is going to burn down again.

Here’s my promise to you: This article is your step-by-step roadmap to finding that hidden “faulty wiring.” We are going to dig deep into the drivers of stroke that traditional medicine rarely tests for—like chronic infections, stealth inflammation, and gut toxicity—and give you an actionable plan to reclaim your vascular health.

Your body is giving you a second chance. Don’t waste it by only treating symptoms. Understanding these hidden stroke risk factors is essential for prevention and recovery.


🔑 Key Takeaways: Your Roadmap to Stroke Prevention

  • Standard Care is NOT Enough: Medications manage risk factors; they don’t fix the underlying inflammation and cellular damage that cause the stroke in the first place.
  • The Gut-Brain Connection is REAL: Your gut bacteria produce chemicals that can directly damage your blood vessels and increase your risk of clotting.
  • It’s NOT Just Cholesterol: We MUST test for advanced markers like Lp(a), oxidized LDL, and inflammatory markers—the ones that truly predict vascular disaster.
  • Inflammation is the ENEMY: Chronic, low-grade inflammation is what makes plaque unstable and causes the deadly clot. Stopping it is NOT OPTIONAL.
  • HBOT and Light Therapy are Game Changers: Therapies like Hyperbaric Oxygen Therapy (HBOT) and Red Light Therapy actively repair brain tissue and accelerate recovery, complementing the functional medicine approach to root cause identification.
  • You Need a Plan, NOT a Pill: A personalized plan based on advanced testing is the only way to truly fix the cause and lower your long-term risk.

Estimated reading time: 13 minutes


The Hidden Truth: Inflammation and a Leaky Gut Caused Your Stroke

You’ve heard about high blood pressure and cholesterol. Everyone talks about that. But let me tell you what my clinical experience shows, and what the latest research confirms: Chronic, systemic inflammation is the fuse that lights the stroke stick of dynamite.

Here’s the scary part: You can have perfect blood pressure and “normal” cholesterol and still have sky-high inflammation destroying your blood vessels from the inside out.

The Vicious Cycle of Gut Toxins and Vascular Damage

When I talk about inflammation, I’m not talking about a twisted ankle. I’m talking about the silent, smoldering fire that starts in your gut.

Here’s what happens:

  1. Leaky Gut: Years of poor diet, stress, and antibiotics damage the lining of your small intestine. This is often called “intestinal permeability.” It’s like your gut’s security fence has holes in it.
  2. Toxins Invade: Undigested food particles, harmful bacteria, and their toxic byproducts (like LPS, or lipopolysaccharide) leak directly into your bloodstream.
  3. The Immune System PANICS: Your immune system sees these invaders and declares war. This war is what we call inflammation.
  4. Vessel Damage: These inflammatory chemicals (cytokines) travel to your brain and heart. They irritate the delicate lining of your blood vessels (the endothelium), causing them to become sticky and damaged. This is what creates the perfect spot for plaque to form and, critically, for a deadly clot to suddenly develop.
  5. The Stroke: When that unstable plaque breaks open, or when a massive inflammatory reaction causes excessive clotting, you get a stroke.

If your doctor hasn’t tested your gut health after a stroke, they’re missing a HUGE piece of the puzzle. You can take all the aspirin in the world, but if your leaky gut is constantly pumping inflammatory chemicals into your blood, you are just waiting for the next crisis.

The Advanced Markers Standard Labs Miss

When your cardiologist checks your labs, they usually look at total cholesterol, LDL, and HDL. That’s like judging the risk of a hurricane by only looking at the air temperature.

This is NOT optional. To truly assess your second stroke risk, we need to look deeper.

What Standard Care ChecksWhat Functional Medicine ChecksWhy It Matters
Total/LDL CholesterolApoB and Oxidized LDLOxidized (damaged) LDL is what actually causes plaque. You can have low LDL, but if it’s all oxidized, you’re at high risk!
C-Reactive Protein (CRP)High-Sensitivity CRP (hs-CRP)We need to see micro-inflammation. A general CRP test can miss the low, chronic inflammation that triggers strokes.
NothingHomocysteine & FibrinogenHigh levels of these indicate genetic or nutritional issues that make your blood thick and sticky (hypercoagulation). This is a direct stroke risk.
NothingLp(a)A largely genetic, highly aggressive risk factor. If you have this, your treatment strategy must change.

If you’ve had a stroke and your doctor hasn’t run tests like these, you have not been properly assessed for your second stroke risk. It’s time to demand a deeper look. (You can check out what the CDC says about traditional stroke risk factors here: CDC stroke information).


Real Patient Story: Doug’s Second Chance

Let me tell you about Doug. He was 58, sharp, and active. Then he suffered an ischemic stroke that left him with significant cognitive and emotional deficits. He was constantly frustrated, couldn’t remember simple things, and felt like he’d lost the ability to connect with his family. Standard physical therapy had plateaued, and his doctors told him he just had to “learn to live with it.”

He was on the standard cocktail of blood pressure meds and a statin, but he felt lousy, and his fear of another stroke was crippling.

This is where Functional Medicine stepped in.

We ran the advanced testing. And guess what? Standard care completely missed this.

  • His hs-CRP (inflammation marker) was through the roof.
  • His stool test revealed a massive yeast overgrowth and low beneficial bacteria—a literal toxic factory in his gut.
  • His organic acid tests showed an inability to properly detoxify from environmental toxins.

Here’s the key: Doug’s body was in a constant state of emergency because of his gut. This systemic inflammation was not only destroying his blood vessels, putting him at high risk for a second stroke, but it was also slowing down his brain’s ability to heal! Standard care was treating his blood pressure; we were treating his survival.

We started a targeted, personalized plan to starve the bad bacteria, seal his leaky gut, and support his body’s natural detoxification pathways. We combined this with powerful neuro-recovery therapies.

His transformation was remarkable. His wife told me he was “back.” He started driving short distances, his memory improved dramatically, and the emotional fog lifted. His lab work backed it up: His inflammation markers plummeted. By fixing his underlying physiology, we didn’t just help his recovery; we dismantled the threat of a second stroke.

(You can read more about Doug’s specific recovery journey, including his use of advanced therapies, in my article: https://darrellkilcupdc.com/2025/11/functional-medicine-stroke-recovery-hbot/)


How Functional Medicine Actually Fixes This

Functional medicine isn’t about replacing your current doctor; it’s about adding a level of investigative depth that the current system isn’t designed for. We are detectives looking for the WHY.

Comprehensive Testing (What Standard Labs Miss)

We can’t treat what we don’t measure. Forget the general blood work. We need specifics.

  • Advanced Lipids and Coagulation: Testing for ApoB, Lp(a), Fibrinogen, and Homocysteine gives us the real picture of how sticky and damaging your blood truly is.
  • Gut Health (The Foundation): We use a comprehensive Stool Analysis to see exactly which bacteria, parasites, or yeast are running the show in your gut. We look for Zonulin or LPS markers to confirm if you have a leaky gut.
  • Inflammation and Stress: Specific tests for hs-CRP and even Adrenal/Hormone panels to see how chronic stress is fueling inflammation. This helps us see if your body is in ‘fight or flight’ mode—which is a major factor in stroke risk. (The National Institutes of Health has a wealth of information on inflammation and stroke: NIH/PubMed research).

Targeted Interventions: Removing the Root Cause

Once we have your specific lab blueprint, the treatment plan is not a guessing game; it’s a direct, targeted attack on your root causes.

Nutrition Strategies: You Are What You Absorb

We don’t do “general healthy eating.” We focus on:

  • Removing the Fire Starters: For most people, this means eliminating inflammatory triggers like gluten, dairy, and processed sugars that feed bad gut bacteria.
  • Sealing the Gut: We use specific nutrients and foods (like bone broth, L-Glutamine, and certain fibers) to repair the intestinal lining. You have to seal the fence before you put in the new plants!
  • Specific Microbiome Support: We use very targeted prebiotics and strain-specific probiotics to crowd out the toxins we found in your stool test. Don’t just buy random probiotics—you need the right strains for your imbalance.
Years of poor diet, stress, and antibiotics damage the lining of your small intestine. This is often called "intestinal permeability." It's like your gut's security fence has holes in it.

Lifestyle Modifications: Making the Brain Resilient

The brain heals best in a state of calm. We work on:

  • Optimizing Sleep: This is where the brain cleans out metabolic waste. Poor sleep is an inflammatory trigger. We may use simple tools like blue light blockers or specific nutrients to support deep, restorative sleep.
  • Stress Resilience: Chronic stress raises cortisol, which directly leads to inflammation and vascular damage. We’ll find simple, powerful ways to activate your “rest and digest” nervous system—whether it’s breathwork, light movement, or a meditation practice.

Integrative Therapies That Accelerate Recovery

While we work on the underlying causes with functional medicine, we can use cutting-edge therapies to speed up your brain’s healing process.

Hyperbaric Oxygen Therapy (HBOT)

We can’t offer this virtually, but if you’re local or can travel, this is a GAME CHANGER.

  • How it Works: You breathe 100% oxygen in a pressurized chamber. This forces oxygen not just into your red blood cells, but into your plasma, allowing it to reach areas of the brain that were previously starved of oxygen due to the stroke.
  • What it Does: It awakens dormant brain cells (penumbra), drastically reduces inflammation, and stimulates the creation of new blood vessels (angiogenesis). For stroke recovery, it’s like a turbocharger for brain healing.

Red Light Therapy (Photobiomodulation)

  • How it Works: Specific wavelengths of red and near-infrared light are applied to the head. This light is absorbed by the powerhouses of your cells, the mitochondria.
  • What it Does: It boosts ATP (energy) production in damaged brain cells, reducing oxidative stress and inflammation right at the site of the injury. This helps the brain heal faster from the initial damage while the functional medicine plan prevents the next attack.

These therapies, combined with the precision of functional medicine, create a powerful one-two punch: Heal the damage while eliminating the underlying cause.


What You Can Do Right Now

Look, I know this is a lot of information. You don’t have to be a doctor to take control. Start small. Here are six actionable steps you can take today to lower your risk and start healing.

  1. Stop Feeding the Fire: For the next 30 days, eliminate processed sugar and refined vegetable oils (like corn, soy, or canola oil). They are the #1 source of internal inflammation. This is your easiest, most immediate win.
  2. Hydrate Your Brain: Your blood needs to flow easily. Drink half your body weight in ounces of clean water every single day. If you weigh 150 lbs, drink 75 oz. Dehydration thickens the blood.
  3. Find Your “Brain Break”: Commit to 10 minutes of complete, mindful rest per day. Not watching TV. Not scrolling. Just 10 minutes of deep, slow breathing. This signals to your nervous system that you are safe, instantly lowering your stress-fueled inflammation.
  4. Demand Deeper Testing: Call your primary care physician or cardiologist and ask for an advanced lipid panel that includes hs-CRP, ApoB, and Homocysteine. If they refuse or don’t know what they are, it’s time to find a Functional Medicine provider.
  5. Eat Your Color: Your diet is not about deprivation; it’s about nutrient density. Eat a wide variety of colorful fruits and vegetables. These contain the antioxidants that protect your blood vessels from the damage inflammation is causing.
  6. Walk with Purpose: You don’t need a marathon, but you need movement. A brisk 30-minute walk gets oxygen to your brain and helps your body flush inflammatory waste. Start slow, but MOVE. (The American Heart Association provides great resources on stroke prevention lifestyle changes: American Heart Association).

FAQ Section: Clearing Up the Confusion

Q: I’m already taking blood thinners and statins. Isn’t that enough to prevent a second stroke?

A: Let me be blunt: No. Your medications are vital, but they are managing the outcome of the disease (blood clots and high cholesterol), not the cause. Functional medicine focuses on removing the triggers—like chronic infection, inflammation, and gut toxins—that force you to need those drugs in the first place. Think of it as patching the holes in the boat while the medications manage the water already inside. We fix the boat so you stop taking on water.

Q: Can a stroke actually be caused by something like a yeast infection in my gut?

A: Yes, absolutely. It’s not the yeast itself that causes the stroke, but the massive inflammatory cascade it triggers. That yeast or bad bacteria (like C. difficile or Candida) releases toxins into your bloodstream. Your immune system fights it, and this chronic low-grade inflammation damages the lining of your arteries over time. We see this link clinically every week. Fix the gut, and the vascular inflammation drops.

Q: How is this “Functional Medicine” approach different from what my neurologist is doing?

A: Your neurologist is a life-saver, specializing in the brain and nervous system structure. My job is to address the underlying body systems that caused the structural damage. They focus on the area above the neck; I focus on the area below the neck that dictates how well the brain can heal and how likely a future event is. We run different tests, look at different systems, and use different tools. We work together to create true, sustainable health.

Q: I live out of state. Can you still help me with the testing and treatment plan?

A: Yes! While we can’t offer in-office therapies like HBOT to people out of state, the core of functional medicine—advanced, deep-dive lab testing and personalized treatment planning—is done virtually. We can send specialized testing kits directly to your home and then conduct all follow-up consultations and treatment recommendations via secure video conferencing. You get the same level of root-cause investigation regardless of where you live.


Conclusion: Don’t Live in Fear—Take Control

The fear of a second stroke is a heavy burden, but it doesn’t have to control you. Standard medicine does an incredible job in the acute phase, but it fails to address the systemic, root-level causes that led to the event.

You have now learned the real drivers of stroke risk: Chronic inflammation, toxic gut health, and missed advanced vascular markers.

Functional medicine is your chance to stop merely managing risk factors and start erasing the root cause. We don’t guess; we test. We don’t use a one-size-fits-all approach; we build a completely personalized roadmap based on your unique biochemistry.

Your body has incredible power to heal and recover, but it needs the right environment and the right support. Take the fear and frustration you feel and turn it into decisive action today. Explore our functional medicine stroke recovery page to learn exactly how we can uncover and address your unique root causes.


Darrell Kilcup, DC, CFMP

Hi there! I’m Dr. Kilcup. You know that health problem you’ve been dealing with – the one that doctors can’t seem to solve, that’s stealing way too much of your time, energy and joy? I can help you get to the bottom that. I am passionate about using the best of science and nutrition to find and fix root causes of health issues. Start your journey towards healing and relief today.

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I have been using the Hyperbaric Oxygen Therapy for the last few weeks and It has helped me so much. I struggle quite a bit with work related stress. When I'm in the chamber I feel completely relaxed, so much so that I can bring my laptop inside and work without stressing. The calmness I feel in the chamber lasts for the remainder of the day as well. I have found too, the more consistent I am with sessions throughout the week the better I feel. The office staff seems well trained in running the tanks too, so I feel safe. I see Dr. Kilcup as well for my brain and gut health. Until now, I don't think I've ever known what "normal" or "healthy" feels like. Thank you all, sincerely!
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